From my experience with healing depression and going through stages of personal growth, as well as observing others processes, too much of something; prolonged trauma, isolation, not expressing or sharing emotional pain, stuckness, etc., leads to further imbalance and worsening of depressive feelings. Some change (perturbation) is usually good for a system-to learn and grow, but again, anything taken to its excess is harmful, i.e., too long in lockdown, too long a heartbreak, too long of the same and things that dont feed your heart creates the seed of depression.
Depression is really often a messenger-saying look here my friend you need to Change this x,y z thing!
We need to challenge the organism.
Whether it is through (relevant examples in the field of science now) getting sick with viruses-which results in immune resilience (makes me wonder do the powers that govern currently, want us to become weak? since their way of handling this virus is absurd from an immunological point of view based on expert opinion Dr D. Cahill eg), or through e.g., psychedelic therapy to disrupt habitual routinized negative thought patterns in depression, (see the latest research on this: example: Prof David Nutt drug science podcast 5. Psychedelics Live Show: Part 1), and all the myriad ways we can disrupt stuck programs, Change is good in moderation!
A good friend once said to me: “If things get really bad-Change something!”